Prepare a flavorful chipotle chicken mozzarella panini with a smoky homemade chipotle mayo, fresh basil, and melted cheese layered inside crisp focaccia. This easy panini recipe is perfect for quick lunches, weeknight dinners, or meal prep. A great option for anyone looking for a fast chicken sandwich idea, a cheesy toasted panini, or a gluten-free sandwich alternative. Ideal for beginners and experienced cooks who want a simple, high-protein meal packed with bold flavor and fresh ingredients.

This flavorful panini combines tender shredded chicken, smoky chipotle mayonnaise, fresh basil, and creamy mozzarella inside crisp focaccia. It’s simple to assemble, quick to prepare, and perfect for an easy lunch or a satisfying weeknight meal.
Ingredients
- 1/4 cup mayonnaise
- 1 chipotle pepper in adobo sauce + 1–2 teaspoons of the sauce
- 4 gluten-free focaccia buns, or 1 focaccia loaf cut into quarters
- 2 cooked chicken breasts (12–14 oz total), shredded
- 8 oz fresh mozzarella, sliced
- 1 tomato, sliced
- 1/2 small red onion, sliced
- 10–12 fresh basil leaves, chopped
Directions
- In a mini food processor, blend the mayonnaise, chipotle pepper, and adobo sauce until smooth.
If you don’t have a food processor, finely chop the pepper and mix everything by hand. - Spread the chipotle mayo on the cut sides of each focaccia bun.
- Layer the shredded chicken, tomato slices, red onion, mozzarella, and basil.
- Close the sandwiches and cook in a panini press over medium-high heat until the bread is crisp and the cheese is melted.
- Serve immediately.
Tips
- Use freshly cooked chicken for the best texture, but rotisserie chicken works well for convenience.
- Pat the tomato slices dry to prevent the panini from getting soggy.
- If the mozzarella is very wet, blot it lightly before adding it to the sandwich.
- Press the panini gently at first, then increase pressure as the cheese begins to melt.

Variations and Substitutions
- Replace chicken with turkey, ham, or roasted vegetables for a meatless option.
- Swap mozzarella for provolone, Monterey Jack, or gouda.
- Use ciabatta, sourdough, or regular sandwich bread if focaccia isn’t available.
- Add avocado or arugula for extra freshness.
- Adjust the adobo sauce quantity to control the heat level.
FAQs
Can I make these ahead?
You can assemble the sandwiches a few hours in advance, but wait to grill them until just before serving.
Can I cook them without a panini press?
Yes. Use a skillet and press the sandwich with another heavy pan.
Is there a gluten-free option?
Yes—use gluten-free focaccia or gluten-free sandwich bread.
Serving Suggestions
- Pair with a simple green salad, coleslaw, or roasted vegetables.
- Serve with sweet potato fries, chips, or a cup of tomato soup.
- Add pickles or a side of extra chipotle mayo for dipping.
Why You’ll Love This Recipe
- Quick and straightforward—ideal for busy days.
- Smoky chipotle flavor balanced with creamy mozzarella.
- Works with many types of bread and proteins.
- Great for meal prep and customizable to your taste.
Chipotle Chicken Mozzarella Panini
4
servings10
minutes4
minutes650
kcalIngredients
-
1/4 cup mayonnaise
-
1 chipotle pepper in adobo sauce + 1–2 teaspoons of the sauce
-
4 gluten-free focaccia buns, or 1 focaccia loaf cut into quarters
-
2 cooked chicken breasts (12–14 oz total), shredded
-
8 oz fresh mozzarella, sliced
-
1 tomato, sliced
-
1/2 small red onion, sliced
-
10–12 fresh basil leaves, chopped
Directions
- In a mini food processor, blend the mayonnaise, chipotle pepper, and adobo sauce until smooth.
- If you don’t have a food processor, finely chop the pepper and mix everything by hand.
- Spread the chipotle mayo on the cut sides of each focaccia bun.
- Layer the shredded chicken, tomato slices, red onion, mozzarella, and basil.
- Close the sandwiches and cook in a panini press over medium-high heat until the bread is crisp and the cheese is melted.
- Serve immediately.








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